Article

Characterization and pharmacological modulation of Alzheimer's disease-associated human microglial states

2026-08-28

Abstract excerpt

Microglia are central mediators of Alzheimer's disease (AD) pathogenesis, yet the mechanisms driving disease-associated microglial states and their therapeutic modulation remain poorly understood. Here, we integrated single-nucleus transcriptomic datasets across the AD spectrum and identified disease- and lipid-associated microglia (DLaM) as a major AD-enriched population linked to genetic risk, neuropathology and...

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Literature Corpus work: 277744d5-f8cf-5567-ac48-bddd97ff23df
DOI: 10.64898/2026.08.26.747247

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