Article

A cross-disease human microglial framework identifies disease-enriched subsets and tool compounds for microglial polarization

2022-06-05

Abstract excerpt

Human microglia play a pivotal role in neurological diseases, but few targeted therapies that directly modulate microglial state or function exist due to an incomplete understanding of microglial heterogeneity. We use single-cell RNA sequencing to profile live human microglia from autopsies or surgical resections across diverse neurological diseases and central nervous system regions. We observe a central divide b...

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Literature Corpus work: e9be4aac-de7d-52e4-a1ce-0ecb349c1395
DOI: 10.1101/2022.06.04.494709

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