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Article

A cellular atlas of <i>Pitx2-</i>dependent cardiac development

14 Jun 2019

Abstract excerpt

ABSTRACT The Pitx2 gene encodes a homeobox transcription factor that is required for mammalian development. Disruption of PITX2 expression in humans causes congenital heart diseases and is associated with atrial fibrillation; however, the cellular and molecular processes dictated by Pitx2 during cardiac ontogeny remain unclear. To characterize the role of Pitx2 during murine heart development we sequenced over...

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PMID: 31201182
DOI: 10.1242/dev.180398

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