Article

Profiling virus-specific Tcf1+ T cell repertoires during acute and chronic viral infection

2020-03-23

Abstract excerpt

CD8 T cells play a crucial role in providing protection from viral infections. It has recently been established that a subset of CD8 T cells expressing Tcf1 are responsible for sustaining exhausted T cells during chronic lymphocytic choriomeningitis virus (LCMV) infection. Many of these studies, however, have been performed using T cell receptor (TCR) transgenic mice, in which CD8 T cells express a monoclonal TCR...

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Literature Corpus work: 27378f6f-0eab-54a0-b9a1-e07daf74f0eb
DOI: 10.1101/2020.03.20.000646

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