Article

Clonally expanded virus-specific CD8 T cells acquire diverse transcriptional phenotypes during acute, chronic, and latent infections

2021-06-30

Abstract excerpt

CD8+ T cells play a crucial role in the control and resolution of viral infections and can adopt a wide range of phenotypes and effector functions depending on the inflammatory context and the duration and extent of antigen exposure. Similarly, viral infections can exert diverse selective pressures on populations of clonally related T cells. Technical limitations have nevertheless made it challenging to investigat...

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Literature Corpus work: 7a345206-8bed-5e43-9573-cf40d5bb73dc
DOI: 10.1101/2021.06.29.450285

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