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Article

Clonally Expanded Virus-Specific CD8 T Cells Acquire Diverse Transcriptional Phenotypes During Acute, Chronic, and Latent Infections.

Frontiers in immunology - 1 Jan 2022

Kuhn Raphael, Sandu Ioana, Agrafiotis Andreas, Hong Kai-Lin, Shlesinger Danielle, Neimeier Daniel, Merkler Doron, Oxenius Annette, Reddy Sai T, Yermanos Alexander

Abstract excerpt

CD8+ T cells play a crucial role in the control and resolution of viral infections and can adopt a wide range of phenotypes and effector functions depending on the inflammatory context and the duration and extent of antigen exposure. Similarly, viral infections can exert diverse selective pressures on populations of clonally related T cells. Technical limitations have nevertheless made it challenging to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35185882
DOI: 10.3389/fimmu.2022.782441
PMCID: PMC8847396

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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