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Article

IGHV1 usage is associated with lymphadenopathy and aggressive disease in the TCL1 mouse model for chronic lymphocytic leukemia

2025-07-01

Abstract excerpt

<title>Abstract</title> <p> TCL1 mice are the most commonly used preclinical model for chronic lymphocytic leukemia (CLL), a B-cell malignancy characterized by clonal CD5 <sup>+</sup> B-lymphocyte accumulation. B-cell receptor (BCR) sequencing identifies two important risk markers, immunoglobulin heavy chain variable region (IGHV) mutational status and receptor stereotypy. Despite the clinical importance in pa...

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Literature Corpus work
4f8120bf-788c-5289-91b0-442cfacea0eb
DOI
10.21203/rs.3.rs-6647193/v1
Open publication

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IGHV1 usage is associated with lymphadenopathy and aggressive disease in the TCL1 mouse model for chronic lymphocytic leukemiaDOI 10.21203/rs.3.rs-6647193/v1
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