Article
Profiling Virus-Specific Tcf1+ T Cell Repertoires During Acute and Chronic Viral Infection.
Frontiers in immunology - 1 Jan 2020
Yermanos Alexander, Sandu Ioana, Pedrioli Alessandro, Borsa Mariana, Wagen Franziska, Oetiker Nathalie, Welten Suzanne P M, Pallmer Katharina, Reddy Sai T, Oxenius Annette
Abstract excerpt
CD8 T cells play a crucial role in providing protection from viral infections. It has recently been established that a subset of CD8 T cells expressing Tcf1 are responsible for sustaining exhausted T cells during chronic lymphocytic choriomeningitis virus (LCMV) infection. Many of these studies, however, have been performed using T cell receptor (TCR) transgenic mice, in which CD8 T cells express a monoclonal TCR...
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