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Characteristics and anatomic location of PD-1 <sup>+</sup> TCF1 <sup>+</sup> stem-like CD8 T cells in chronic viral infection and cancer

2 Oct 2023

Abstract excerpt

CD8 T cells play an essential role in antitumor immunity and chronic viral infections. Recent findings have delineated the differentiation pathway of CD8 T cells in accordance with the progenitor-progeny relationship of TCF1 + stem-like and Tim-3 + TCF1 − more differentiated T cells. Here, we investigated the characteristics of stem-like and differentiated CD8 T cells isolated from several murine tumor models and...

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PMID: 37782797
DOI: 10.1073/pnas.2221985120

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