Article
Tcf1+ cells are required to maintain the inflationary T cell pool upon MCMV infection.
Nature communications - 8 May 2020
Welten Suzanne P M, Yermanos Alexander, Baumann Nicolas S, Wagen Franziska, Oetiker Nathalie, Sandu Ioana, Pedrioli Alessandro, Oduro Jennifer D, Reddy Sai T, Cicin-Sain Luka, Held Werner, Oxenius Annette
Abstract excerpt
Cytomegalovirus-based vaccine vectors offer interesting opportunities for T cell-based vaccination purposes as CMV infection induces large numbers of functional effector-like cells that accumulate in peripheral tissues, a process termed memory inflation. Maintenance of high numbers of peripheral CD8 T cells requires continuous replenishment of the inflationary T cell pool. Here, we show that the inflationary T...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.