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Article

High antigen levels induce an exhausted phenotype in a chronic infection without impairing T cell expansion and survival.

The Journal of experimental medicine - 22 Aug 2016

Utzschneider Daniel T, Alfei Francesca, Roelli Patrick, Barras David, Chennupati Vijaykumar, Darbre Stephanie, Delorenzi Mauro, Pinschewer Daniel D, Zehn Dietmar

Abstract excerpt

Chronic infections induce T cells showing impaired cytokine secretion and up-regulated expression of inhibitory receptors such as PD-1. What determines the acquisition of this chronic phenotype and how it impacts T cell function remain vaguely understood. Using newly generated recombinant antigen variant-expressing chronic lymphocytic choriomeningitis virus (LCMV) strains, we uncovered that T cell differentiation...

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Identifiers

PMID: 27455951
DOI: 10.1084/jem.20150598
PMCID: PMC4995073

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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