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Article

"Viral deja vu" elicits organ-specific immune disease independent of reactivity to self

6 Apr 2006

Abstract excerpt

Autoimmune diseases are often precipitated by viral infections. Yet our current understanding fails to explain how viruses trigger organ-specific autoimmunity despite thymic tolerance extending to many non-lymphohematopoietic self antigens. Additionally, a key epidemiological finding needs to be explained: In genetically susceptible individuals, early childhood infections seem to predispose them to multiple...

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PMID: 16604192
DOI: 10.1172/jci27372

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