Article

Time-resolved systems analysis reveals a critical role of XCR1+ dendritic cells in the maintenance of effector T cells during chronic viral infection

2018-11-22

Abstract excerpt

Upon a viral infection, the host immune system attempts to eradicate the virus. However, once the infection threat seems overwhelming, the infected host actively shuts down effector responses to reduce immunopathology. The price to pay for this is the establishment of a chronic infection that is only partially controlled by a lower level immune response. The genetic networks underlying this infection fate decision...

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Identifiers and source

Literature Corpus work: 9939c40a-803c-57f0-947c-ad3b80e01062
DOI: 10.1101/476077

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