Article

Topological data analysis reveals principles of chromosome structure throughout cellular differentiation

2019-02-05

Abstract excerpt

Three-dimensional chromosome structure has a significant influence in many diverse genomic processes and has recently been shown to relate to cellular differentiation. Many methods for describing the chromosomal architecture focus on specific substructures such as topologically-associating domains (TADs) or compartments, but we are still missing a global view of all geometric features of chromosomes. Topological d...

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Literature Corpus work: 1e959dff-bcda-5f28-b215-350e0ca71b6b
DOI: 10.1101/540716

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