Article
The presence of copy number variants in specific topologically associating domains has prognostic value in many cancer types
2019-09-23
Abstract excerpt
The human genome is organized into topologically associating domains (TADs), which represent contiguous regions with a higher frequency of intra-interactions as opposed to inter-interactions. TADs contribute to gene expression regulation by restricting interactions between regulatory elements, and their disruption by genomic rearrangements can result in altered gene expression and, ultimately, in cancer. Here, we...
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Identifiers and source
- Literature Corpus work
- 646fba13-c101-5bea-a25a-597476e2b8f7
- DOI
- 10.1101/777573