Article

TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer’s disease models

2024-03-11

Abstract excerpt

<h4>SUMMARY</h4> Human genetics implicate defective myeloid responses in the development of late onset, age-associated Alzheimer’s disease (AD). Aging is characterized by a decline in myeloid metabolism that triggers maladaptive, neurotoxic immune responses. TREM1 is an amplifier of pro-inflammatory myeloid responses, and here we find that Trem1 deficiency prevents age-dependent changes in myeloid metabolism, in...

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Literature Corpus work: b093a414-fbac-5e16-b7e6-4049b80d4cfe
DOI: 10.1101/2024.03.05.583562

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