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Article

Up-regulated succinylation modifications induce a senescence phenotype in microglia by altering mitochondrial energy metabolism.

Journal of neuroinflammation - 14 Nov 2024

Zhao Xinnan, Yang Xiaohan, Du Cong, Hao Huimin, Liu Shuang, Liu Gang, Zhang Guangyin, Fan Kai, Ma Jianmei

Abstract excerpt

The aging of the central nervous system(CNS) is a primary contributor to neurodegenerative diseases in older individuals and significantly impacts their quality of life. Neuroinflammation, characterized by activation of microglia(MG) and release of cytokines, is closely associated with the onset of these neurodegenerative diseases. The activated status of MG is modulated by specifically programmed metabolic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39543710
DOI: 10.1186/s12974-024-03284-4
PMCID: PMC11566524

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