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Article

Microglia reprogram metabolic profiles for phenotype and function changes in central nervous system.

Neurobiology of disease - 1 May 2021

Yang Sheng, Qin Chuan, Hu Zi-Wei, Zhou Luo-Qi, Yu Hai-Han, Chen Man, Bosco Dale B, Wang Wei, Wu Long-Jun, Tian Dai-Shi

Abstract excerpt

In response to various types of environmental and cellular stress, microglia rapidly activate and exhibit either pro- or anti-inflammatory phenotypes to maintain tissue homeostasis. Activation of microglia can result in changes in morphology, phagocytosis capacity, and secretion of cytokines. Furthermore, microglial activation also induces changes to cellular energy demand, which is dependent on the metabolism of...

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PMID: 33556540
DOI: 10.1016/j.nbd.2021.105290

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