Article

Microglial signalling pathway deficits associated with the R47H TREM2 variant linked to AD indicate inability to activate inflammasome

2020-09-09

Abstract excerpt

The R47H variant of the microglial membrane receptor TREM2 is linked to increased risk of late onset Alzheimer’s disease. Human induced pluripotent stem cell derived microglia (iPS-Mg) from patient iPSC lines expressing the AD-linked R47H het TREM2 variant, common variant (Cv) or an R47H hom CRISPR edited line and its isogeneic control, demonstrated that R47H-expressing iPS-Mg expressed a deficit in signal trans...

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Literature Corpus work: 78617453-8ff7-5a8a-aeb2-8872e998647e
DOI: 10.1101/2020.09.08.288043

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