Article

C9orf72 Repeat Expansion Induces Metabolic Dysfunction in Human iPSC-Derived Microglia and Modulates Glial–Neuronal Crosstalk

2025-03-15

Abstract excerpt

The C9orf72 hexanucleotide repeat expansion mutation is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia, but its cell type-specific effects on energy metabolism and immune pathways remain poorly understood. Using induced pluripotent stem cell (iPSC)-derived motor neurons, astrocytes and microglia from C9orf72 patients and their isogenic controls, we investigated met...

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Literature Corpus work: 7c895ada-3d80-55d3-89df-04a4c7cebc16
DOI: 10.1101/2025.03.14.643263

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