Article

IFIH1 (MDA5) is required for innate immune detection of intron-containing RNA expressed from the HIV-1 provirus

2023-11-18

Abstract excerpt

<h4>ABSTRACT</h4> Antiretroviral therapy (ART) suppresses HIV-1 viremia and prevents progression to AIDS. Nonetheless, chronic inflammation is a common problem for people living with HIV-1 on ART. One possible cause of inflammation is ongoing transcription from HIV-1 proviruses, whether or not the sequences are competent for replication. Previous work has shown that intron-containing RNA expressed from the HIV-1...

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Literature Corpus work: 2679adbe-f0dc-5db0-a25c-f530b2b803f9
DOI: 10.1101/2023.11.17.567619

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