Article

IFIH1 loss-of-function predisposes to inflammatory and SARS-CoV-2-related infectious diseases

2023-10-30

Abstract excerpt

<title>Abstract</title> <p>The <italic>IFIH1</italic> gene, encoding melanoma differentiation-associated protein 5 (MDA5), is an indispensable innate immune regulator involved in the early detection of viral infections. Previous studies described MDA5 dysregulation linking it to weakened immunological responses, and increased susceptibility to microbial infections and autoimmune disorders. Monoallelic gain-of-fun...

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Literature Corpus work: 5ce053c2-97a5-5fb9-a254-3c57973fd9d3
DOI: 10.21203/rs.3.rs-3482379/v1

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