Article

<i>IFIH1</i>loss-of-function predisposes to inflammatory and SARS-CoV-2-related infectious diseases

2023-10-15

Abstract excerpt

The IFIH1 gene, encoding melanoma differentiation-associated protein 5 (MDA5), is an indispensable innate immune regulator involved in the early detection of viral infections. Previous studies described MDA5 dysregulation linking it to weakened immunological responses, and increased susceptibility to microbial infections and autoimmune disorders. Monoallelic gain-of-function of the IFIH1 gene has been associated w...

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Literature Corpus work: 5c2386a6-14fb-5a3e-b6a5-b1308a4c3bd1
DOI: 10.1101/2023.10.13.23297034

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