Article

Identification of the cellular transcription factor KLF16 as a novel repressive epigenetic repressor of HIV-1 transcription

2026-05-04

Abstract excerpt

<h4>Summary</h4> Despite antiretroviral therapy, human immunodeficiency virus type 1 (HIV-1) persists in latently-infected cells through epigenetic and transcriptional mechanisms. Latency-reversing agents have failed clinically, partly due to incomplete understanding of HIV-1 latency reversal. Here, using DNA-affinity capture and mass spectrometry on the HIV-1 5’ long terminal repeat (5’LTR) enhancer-core promote...

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Literature Corpus work: b955eedd-b343-5337-bd9c-7e0dc77ef15a
DOI: 10.64898/2026.05.02.722432

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