Article

C19ORF66 is an Interferon-Stimulated Gene (ISG) which Inhibits Human Immunodeficiency Virus-1

2016-04-26

Abstract excerpt

<h4>ABSTRACT</h4> Innate immunity is the first line of defense against invading microbes 1 . The type I interferon (IFN) pathway plays a key role in controlling Human Immunodeficiency Virus type 1 (HIV-1) replication 2,3 . We identified an IFN-α stimulated gene C19ORF66 that we term Suppressor of Viral Activity (SVA). Full length SVA-1 protein inhibits HIV-1 by blocking virion production. SVA splice variants tr...

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Identifiers and source

Literature Corpus work: 4ff8c6ac-a07c-5cfb-a39b-e7afeda75280
DOI: 10.1101/050310

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