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Article

5’ cap sequestration is required for sensing of unspliced HIV-1 RNA by MDA5

2025-08-25

Abstract excerpt

<h4>ABSTRACT</h4> Heterogenous transcription start site (TSS) usage dictates the structure and function of unspliced HIV-1 RNAs (usRNA). We and others have previously reported that expression and Rev/CRM1-mediated nuclear export of HIV-1 usRNA in macrophages activates MDA5, MAVS, and innate immune signaling cascades. In this study, we reveal that MDA5 sensing of viral usRNA is strictly determined by TSS, 5’ leade...

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Identifiers and source

Literature Corpus work
31e79a61-af07-5759-a7f2-057a38bd7db7
DOI
10.1101/2025.08.20.671346
Open publication

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5’ cap sequestration is required for sensing of unspliced HIV-1 RNA by MDA5DOI 10.1101/2025.08.20.671346
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