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Article

IFIH1 loss of function predisposes to inflammatory and SARS-CoV-2-related infectious diseases.

Scandinavian journal of immunology - 1 Aug 2024

Najm Rania, Yavuz Lemis, Jain Ruchi, El Naofal Maha, Ramaswamy Sathishkumar, Abuhammour Walid, Loney Tom, Nowotny Norbert, Alsheikh-Ali Alawi, Abou Tayoun Ahmad, Kandasamy Richard K

Abstract excerpt

The IFIH1 gene, encoding melanoma differentiation-associated protein 5 (MDA5), is an indispensable innate immune regulator involved in the early detection of viral infections. Previous studies described MDA5 dysregulation in weakened immunological responses, and increased susceptibility to microbial infections and autoimmune disorders. Monoallelic gain-of-function of the IFIH1 gene has been associated with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 38757311
DOI: 10.1111/sji.13373

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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