Article

Direct RNA-Mediated Epigenetic Silencing of Innate Immune Genes by HIV-1: Integrated Mechanistic and Clinical Evidence

2025-12-02

Abstract excerpt

<title>Abstract</title> <p>Background HIV-1 establishes persistent infection through complex epigenetic manipulation of host immune responses. While viral protein-mediated mechanisms are well characterized, the direct involvement of HIV-1-derived RNAs in epigenetic regulation remains incompletely understood. Methods We employed an integrated approach combining DNA:RNA hybrid immunoprecipitation (DRIP-qPCR), chrom...

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Literature Corpus work: 7976a231-6b79-5b34-b8f9-e2e489097bc0
DOI: 10.21203/rs.3.rs-8167788/v1

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Direct RNA-Mediated Epigenetic Silencing of Innate Immune Genes by HIV-1: Integrated Mechanistic and Clinical EvidenceDOI 10.21203/rs.3.rs-8167788/v1Read

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