Article

Identification of the cellular factor KLF16 as a novel epigenetic repressor of HIV-1 transcription

2026-06-04

Abstract excerpt

<title>Abstract</title> <p>Despite antiretroviral therapy, human immunodeficiency virus type 1 (HIV-1) persists in latently-infected cells through epigenetic and transcriptional mechanisms. Latency-reversing agents have failed clinically, partly due to incomplete understanding of HIV -1 latency reversal. Here, using DNA-affinity capture and mass spectrometry on the HIV -1 5’ long terminal repeat (5'LTR) enhancer-...

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Literature Corpus work: b62878ab-7052-5df3-918d-d46f00255fa4
DOI: 10.21203/rs.3.rs-9683098/v1

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