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Article

Delineation of a thrombin receptor-stimulated vascular smooth muscle cell transition generating cells in the plaque-stabilizing fibrous cap.

Cardiovascular research - 14 Aug 2025

Taylor James C K, Worssam Matthew D, Oc Sebnem, Lambert Jordi, Mahbubani Krishnaa T, Foote Kirsty, Finigan Allie, Chan Yee-Hung, Figg Nichola, Clarke Murray C H, Bennett Martin R, Jørgensen Helle F

Abstract excerpt

AIMS: Vascular smooth muscle cells (VSMCs) accumulate in atherosclerotic plaques and exhibit remarkable phenotypic plasticity, contributing to both plaque growth and stability. The plaque-stabilizing fibrous cap is rich in VSMC-derived cells, yet the cellular transitions and regulatory mechanisms governing fibrous cap formation remain unclear. Here, we aimed to identify the VSMC phenotypic transitions associated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40577585
DOI: 10.1093/cvr/cvaf112
PMCID: PMC12352313

Genes

NOTCH3
VCAM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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