Article
Endothelial-to-mesenchymal transition gene signature derived from single-cell transcriptomics of human atherosclerotic tissue associates with stable plaque histological characteristics.
Vascular pharmacology - 1 Jun 2025
Slenders Lotte, Wesseling Marian, Wei Siting, Boltjes Arjan, Kapteijn Daniek M C, van de Kraak Petra, Depuydt Marie A C, Prange Koen H M, van den Dungen Noortje A M, Benavente Ernest D, de Kleijn Dominique P V, de Borst Gert J, de Winther Menno P J, den Ruijter Hester M, Owens Gary K, Pasterkamp Gerard, Mokry Michal
Abstract excerpt
BACKGROUND: Endothelial cells within atherosclerotic plaques can differentiate into a mesenchymal-like phenotype through endothelial-to-mesenchymal transition (EndoMT). Our understanding of the molecular mechanisms underlying EndoMT in human atherosclerosis remains limited. Current gene expression signatures are often derived from in vitro experiments or animal studies and typically reflect genes upregulated in...
Topics
Join the communities discussing this publication.