Article
Comprehensive Integration of Multiple Single-Cell Transcriptomic Data Sets Defines Distinct Cell Populations and Their Phenotypic Changes in Murine Atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2024
Sharma Disha, Worssam Matthew D, Pedroza Albert J, Dalal Alex R, Alemany Haizea, Kim Hyun-Jung, Kundu Ramendra, Fischbein Michael P, Cheng Paul, Wirka Robert, Quertermous Thomas
Abstract excerpt
BACKGROUND: The application of single-cell transcriptomic (single-cell RNA sequencing) analysis to the study of atherosclerosis has provided unique insights into the molecular and genetic mechanisms that mediate disease risk and pathophysiology. However, nonstandardized methodologies and relatively high costs associated with the technique have limited the size and replication of existing data sets and created...
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