Article

Functional genomic dissection of MS risk loci reveals convergence of cis and trans gene regulatory mechanisms in microglia

2025-06-20

Abstract excerpt

<h4>Summary</h4> Neurological diseases (NDs) are a major source of unmet medical need, and translational insights have been hampered by complex underlying pathophysiologies and limitations of experimental models. Noncoding single nucleotide polymorphisms (SNPs) at hundreds of loci have been linked to ND risk by genome-wide association studies (GWAS), but the causal genes and pathways are largely unknown. Despite t...

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Literature Corpus work: 66f83a66-8548-5f3a-bd76-eff4bbeade41
DOI: 10.1101/2025.06.16.25329681

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