Article

Functional Genomic Profiling of Schizophrenia-Associated Genes Reveals Key Microglial Regulators

2025-11-14

Abstract excerpt

Microglia are increasingly recognized as key regulators of neural circuit development and putative contributors to the pathophysiology of neuropsychiatric disorders such as schizophrenia (SCZ). However, the functional impact of SCZ-associated genes in microglia remains largely unexplored. Here, we performed an arrayed CRISPR targeting screen of 30 schizophrenia-associated genes predicted to be differentially expre...

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Literature Corpus work: 00be1dd5-d0a1-5928-8a0d-1ec04671882f
DOI: 10.1101/2025.11.14.688490

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