Article

Chromatin context-dependent regulation and epigenetic manipulation of prime editing

2023-04-12

Abstract excerpt

<h4>ABSTRACT</h4> Prime editing is a powerful means of introducing precise changes to specific locations in mammalian genomes. However, the widely varying efficiency of prime editing across target sites of interest has limited its adoption in the context of both basic research and clinical settings. Here, we set out to exhaustively characterize the impact of the cis- chromatin environment on prime editing effici...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 25e62f3b-1c90-54a2-b36f-9a5985fc52b8
DOI: 10.1101/2023.04.12.536587

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Chromatin context-dependent regulation and epigenetic manipulation of prime editingDOI 10.1101/2023.04.12.536587Read

Prime Editing Efficiency and Fidelity are Enhanced in the Absence of Mismatch RepairSemantic proximity Read

Editing the Epigenome: Reshaping the Genomic Landscape.Semantic proximity Read

Detecting Methylation Changes Induced by Prime EditingSemantic proximity Read

Enhanced prime editing systems by manipulating cellular determinants of editing outcomes.Semantic proximity Read

Analyzing the functional effects of DNA variants with gene editing.Semantic proximity Read

Greater Than the Sum of Parts: Complexity of the Dynamic Epigenome.Semantic proximity Read

From profiles to function in epigenomics.Semantic proximity Read

Coupled single-cell CRISPR screening and epigenomic profiling reveals causal gene regulatory networksSemantic proximity Read

Cell-stereotyped DNA repair outcomes are widespread during genome editingSemantic proximity Read

Genomic landscape of oxidative DNA damage and repair reveals regioselective protection from mutagenesisSemantic proximity Read

High throughput PRIME editing screens identify functional DNA variants in the human genomeSemantic proximity Read

MSH2 and MSH6 as size dependent cellular determinants for prime editing in human embryonic stem cellsSemantic proximity Read