Article
Prime Editing Efficiency and Fidelity are Enhanced in the Absence of Mismatch Repair
2021-09-30
Abstract excerpt
Prime editing (PE) is a powerful genome engineering approach that enables the introduction of base substitutions, insertions and deletions into any given genomic locus. However, the efficiency of PE varies widely and depends not only on the genomic region targeted, but also on the genetic background of the edited cell. To determine which cellular factors affect PE efficiency, we carried out a focused genetic scree...
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Identifiers and source
- Literature Corpus work
- 0b21807f-5430-5f5c-8123-e621b935bf48
- DOI
- 10.1101/2021.09.30.462548