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Article

Analyzing the functional effects of DNA variants with gene editing.

Cell reports methods - 20 May 2024

Cooper Sarah, Obolenski Sofia, Waters Andrew J, Bassett Andrew R, Coelho Matthew A

Abstract excerpt

Continual advancements in genomics have led to an ever-widening disparity between the rate of discovery of genetic variants and our current understanding of their functions and potential roles in disease. Systematic methods for phenotyping DNA variants are required to effectively translate genomics data into improved outcomes for patients with genetic diseases. To make the biggest impact, these approaches must be...

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Identifiers

PMID: 38744287
DOI: 10.1016/j.crmeth.2024.100776
PMCID: PMC11133854

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