Article
Editing the Epigenome: Reshaping the Genomic Landscape.
Annual review of genomics and human genetics - 31 Aug 2018
Holtzman Liad, Gersbach Charles A
Abstract excerpt
The eukaryotic epigenome has an instrumental role in determining and maintaining cell identity and function. Epigenetic components such as DNA methylation, histone tail modifications, chromatin accessibility, and DNA architecture are tightly correlated with central cellular processes, while their dysregulation manifests in aberrant gene expression and disease. The ability to specifically edit the epigenome holds...
Topics
- CRISPR-Cas Systems
- DNA Methylation
- Epigenomics
- Gene Editing
- Gene Expression Regulation
- Genetic Predisposition to Disease
- Genome
- Histone Code
- Humans
- Protein Processing, Post-Translational