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Article

Detecting Methylation Changes Induced by Prime Editing

2025-04-17

Abstract excerpt

While prime editing offers improved precision compared to traditional CRISPR-Cas9 systems, concerns remain regarding potential off-target effects, including epigenetic changes such as DNA methylation. In this study, we investigated whether prime editing induces aberrant CpG methylation patterns. Whole-genome bisulfite sequencing revealed overall methylation similarity between Cas9-edited, and PE2-edited cells. How...

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Identifiers and source

Literature Corpus work
69bec267-4589-52de-83c5-a8dab074d8c1
DOI
10.20944/preprints202504.1502.v1
Open publication

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Detecting Methylation Changes Induced by Prime EditingDOI 10.20944/preprints202504.1502.v1
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