Article

Alternative Polyadenylation Regulates Patient-specific Tumor Growth by Individualizing the MicroRNA Target Site Landscape

2019-04-07

Abstract excerpt

<h4>Background</h4> Alternative polyadenylation (APA) shortens or lengthens the 3’-untranslated region (3’-UTR) of hundreds of genes in cancer. While APA genes modify microRNA target sites in the 3’-UTRs to promote tumorigenesis, previous studies have focused on a subset of the modification landscape. <h4>Method</h4> For comprehensive understanding of the function of global APA events, we consider the total targ...

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Literature Corpus work: 25cc31aa-1e5f-5e5c-90a4-68eb6686ba95
DOI: 10.1101/601518

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