Article

3′-UTR shortening contributes to subtype-specific cancer growth by breaking stable ceRNA crosstalk of housekeeping genes

2019-04-07

Abstract excerpt

<h4>ABSTRACT</h4> Shortening of 3′UTRs (3′US) through alternative polyadenylation (APA) is a post-transcriptional mechanism that regulate expression of hundreds of genes in human cancers. In breast cancer, different subtypes of tumor samples, such as estrogen receptor positive and negative (ER+ and ER-), are characterized by distinct molecular mechanisms, suggesting possible differences in the post-transcriptiona...

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Literature Corpus work: 10c77e56-b0db-54af-80cd-2dabe25effec
DOI: 10.1101/601526

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