Article
Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging.
Cell stem cell - 1 Aug 2024
Jakobsen Niels Asger, Turkalj Sven, Zeng Andy G X, Stoilova Bilyana, Metzner Marlen, Rahmig Susann, Nagree Murtaza S, Shah Sayyam, Moore Rachel, Usukhbayar Batchimeg, Angulo Salazar Mirian, Gafencu Grigore-Aristide, Kennedy Alison, Newman Simon, Kendrick Benjamin J L, Taylor Adrian H, Afinowi-Luitz Rasheed, Gundle Roger, Watkins Bridget, Wheway Kim, Beazley Debra, Murison Alex, Aguilar-Navarro Alicia G, Flores-Figueroa Eugenia, Dakin Stephanie G, Carr Andrew J, Nerlov Claus, Dick John E, Xie Stephanie Z, Vyas Paresh
Abstract excerpt
Clonal hematopoiesis (CH) arises when hematopoietic stem cells (HSCs) acquire mutations, most frequently in the DNMT3A and TET2 genes, conferring a competitive advantage through mechanisms that remain unclear. To gain insight into how CH mutations enable gradual clonal expansion, we used single-cell multi-omics with high-fidelity genotyping on human CH bone marrow (BM) samples. Most of the selective advantage of...
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