Article
Clonal hematopoiesis: mechanisms driving dominance of stem cell clones.
Blood - 1 Oct 2020
Challen Grant A, Goodell Margaret A
Abstract excerpt
The discovery of clonal hematopoiesis (CH) in older individuals has changed the way hematologists and stem cell biologists view aging. Somatic mutations accumulate in stem cells over time. While most mutations have no impact, some result in subtle functional differences that ultimately manifest in distinct stem cell behaviors. With a large pool of stem cells and many decades to compete, some of these differences...
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