Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Discovering the drivers of clonal hematopoiesis.

Nature communications - 23 Jul 2022

Pich Oriol, Reyes-Salazar Iker, Gonzalez-Perez Abel, Lopez-Bigas Nuria

Abstract excerpt

Mutations in genes that confer a selective advantage to hematopoietic stem cells (HSCs) drive clonal hematopoiesis (CH). While some CH drivers have been identified, the compendium of all genes able to drive CH upon mutations in HSCs remains incomplete. Exploiting signals of positive selection in blood somatic mutations may be an effective way to identify CH driver genes, analogously to cancer. Using the tumor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hematopoiesis
Share to Hematopoietic Stem Cells
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasms

Share to Acute Myeloid Leukemia Research

Share to Cancer Genomics and Diagnostics

Share to Clonal Hematopoiesis

Share to Single-cell and spatial transcriptomics

Source

Open in PubMed Open full text

Identifiers

PMID: 35871184
DOI: 10.1038/s41467-022-31878-0
PMCID: PMC9308779

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Discovering the drivers of clonal hematopoiesis.PMID 35871184Read ↗

Discovering the drivers of clonal hematopoiesisSemantic proximity Read ↗

Identification of Clonal Hematopoiesis Driver Mutations through In Silico Saturation MutagenesisSemantic proximity Read ↗

Analysis of somatic mutations in whole blood from 200,618 individuals identifies pervasive positive selection and novel drivers of clonal hematopoiesis.Semantic proximity Read ↗

Identification of Clonal Hematopoiesis Driver Mutations through In Silico Saturation Mutagenesis.Semantic proximity Read ↗

Gene-Specific Machine Learning Models to Classify Driver Mutations in Clonal Hematopoiesis.Semantic proximity Read ↗

Detection and Characterization of Clonal Hematopoiesis.Semantic proximity Read ↗

Genome-wide characterization of clonal hematopoiesis reveals extensive non-coding putative driver mutationsSemantic proximity Read ↗

Causes and consequences of clonal hematopoiesis.Semantic proximity Read ↗

The evolutionary dynamics and fitness landscape of clonal hematopoiesis.Semantic proximity Read ↗

Clonal Hematopoiesis: Impact on Health and DiseaseSemantic proximity Read ↗

Molecular Pathways in Clonal Hematopoiesis: From the Acquisition of Somatic Mutations to Transformation into Hematologic NeoplasmSemantic proximity Read ↗

Clonal hematopoiesis and hematological malignancy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.