Article

Network-Based Analysis of Human Astrocytes Links Aging to Neurodegenerative and Cardiovascular Diseases

2025-11-06

Abstract excerpt

Astrocytes are central to brain homeostasis, supporting neuronal metabolism, synaptic activity, and the blood–brain barrier. With aging, these glial cells undergo molecular and functional changes that weaken support functions and promote neuroinflammation, contributing to neurodegeneration. Yet the systems-level mechanisms of astrocytic aging remain poorly defined in human models. Because aging also heightens risk...

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Literature Corpus work: 2504a064-1a29-5737-81c4-0169cb2a834f
DOI: 10.1101/2025.11.05.686746

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