Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology.

doi:10.1038/s41467-021-27702-w

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Article

Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology.

Nature communications - 10 Jan 2022

Jiwaji Zoeb, Tiwari Sachin S, Avilés-Reyes Rolando X, Hooley Monique, Hampton David, Torvell Megan, Johnson Delinda A, McQueen Jamie, Baxter Paul, Sabari-Sankar Kayalvizhi, Qiu Jing, He Xin, Fowler Jill, Febery James, Gregory Jenna, Rose Jamie, Tulloch Jane, Loan Jamie, Story David, McDade Karina, Smith Amy M, Greer Peta, Ball Matthew, Kind Peter C, Matthews Paul M, Smith Colin, Dando Owen, Spires-Jones Tara L, Johnson Jeffrey A, Chandran Siddharthan, Hardingham Giles E

Abstract excerpt

Alzheimer's disease (AD) alters astrocytes, but the effect of Aß and Tau pathology is poorly understood. TRAP-seq translatome analysis of astrocytes in APP/PS1 ß-amyloidopathy and MAPTP301S tauopathy mice revealed that only Aß influenced expression of AD risk genes, but both pathologies precociously induced age-dependent changes, and had distinct but overlapping signatures found in human post-mortem AD...

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Identifiers

PMID: 35013236
DOI: 10.1038/s41467-021-27702-w
PMCID: PMC8748982

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