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Article

Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype.

Neurobiology of aging - 1 Oct 2011

Simpson Julie E, Ince Paul G, Shaw Pamela J, Heath Paul R, Raman Rohini, Garwood Claire J, Gelsthorpe Catherine, Baxter Lynne, Forster Gillian, Matthews Fiona E, Brayne Carol, Wharton Stephen B

Abstract excerpt

Astrocytes contribute to a variety of functions in the brain, including homeostasis, synapse formation, plasticity, and metabolism. Astrocyte dysfunction may disrupt their normal role, including neuronal support, thereby contributing to neurodegenerative pathologies, including Alzheimer's disease...

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Source

Identifiers

PMID: 21705112
DOI: 10.1016/j.neurobiolaging.2011.04.013

Genes

APOE
GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21705112-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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