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Alzheimer's disease is associated with altered expression of genes involved in immune response and mitochondrial processes in astrocytes

3 Oct 2014

Abstract excerpt

Alzheimer's disease (AD) is characterized by deficits in cerebral metabolic rates of glucose in the posterior cingulate (PC) and precuneus in AD subjects, and in APOEε4 carriers, decades before the onset of measureable cognitive deficits. However, the cellular and molecular basis of this phenotype remains to be clarified. Given the roles of astrocytes in energy storage and brain immunity, we sought to...

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PMID: 25448601
DOI: 10.1016/j.neurobiolaging.2014.09.027

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