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Contributions of Genetic Variation in Astrocytes to Cell and Molecular Mechanisms of Risk and Resilience to Late-Onset Alzheimer's Disease.

Glia - 1 Jun 2025

Lee Hyo, Pearse Richard V, Lish Alexandra M, Pan Cheryl, Augur Zachary M, Terzioglu Gizem, Gaur Pallavi, Liao Meichen, Fujita Masashi, Tio Earvin S, Duong Duc M, Felsky Daniel, Seyfried Nicholas T, Menon Vilas, Bennett David A, De Jager Philip L, Young-Pearse Tracy L

Abstract excerpt

Reactive astrocytes are associated with Alzheimer's disease (AD), and several AD genetic risk variants are associated with genes highly expressed in astrocytes. However, the contribution of genetic risk within astrocytes to cellular processes relevant to the pathogenesis of AD remains ill-defined. Here, we present a resource for studying AD genetic risk in astrocytes using a large collection of induced...

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PMID: 39901616
DOI: 10.1002/glia.24677
PMCID: PMC12012329

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