Article

Transcriptomic profiling of the middle temporal gyrus reveals differential glial/neuronal dysregulation across Alzheimer’s disease and aging

2025-10-20

Abstract excerpt

Alzheimer’s disease (AD), the most common cause of dementia, is characterized by amyloid-β plaques, neurofibrillary tangles, and widespread neuronal dysfunction. Aging, the strongest risk factor for AD, is also associated with some overlapping processes, such as neuronal cell transcriptional downregulation and glial cell activation. The middle temporal gyrus (MTG) is a brain region that supports semantic processin...

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Literature Corpus work: 5b1b36f5-082c-5321-bd34-410b652bd442
DOI: 10.1101/2025.10.19.683343

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